America’s love affair with the open road is legendary. The freedom to drive, the thrill of discovery, and the sheer variety of landscapes have made road trips a cherished tradition. From deserts and oceans to forests and mountains, the highways of the United States are more than just pavement—they're living stories, cultural time capsules, and paths to unforgettable memories.

Let’s hit the road and explore the 10 most famous highways in America, each with its personality, history, and jaw-dropping views.

#1 – The Mother Road: Historic Route 66

Often dubbed “The Mother Road,” Route 66 is perhaps the most iconic highway in the United States. Stretching from Chicago, Illinois, to Santa Monica, California, this road carved a path through the heart of America, serving as a lifeline for Dust Bowl migrants and a symbol of post-war adventure.

Commissioned in 1926
Total length: 2,448 miles
Became a key route during westward expansion and the Great Depression

Photo: unsplash.com/@michelleoudemaatman

#2 – Pacific Coast Highway (California SR 1)

Imagine ocean waves crashing against rugged cliffs while you cruise with the windows down — the Pacific Coast Highway or California State Route 1.

This route hugs California’s coastline, offering some of the most picturesque views in the world.

Key Stops

Big Sur: Jaw-dropping cliffs and coastal views
Monterey: Marine life and cannery row charm
Malibu: Celeb spotting and beachside bliss

Photo: unsplash.com/@danhadar

#3 – Overseas Highway (Florida Keys)

Ever dreamed of driving over the ocean? The Overseas Highway connects Miami to Key West, crossing 42 bridges and dozens of tropical islands.

Seven Mile Bridge: One of the longest bridges in the world
Crystal-clear waters and coral reefs visible from the road
Sunsets that will leave you speechless

This unique drive offers a tropical twist to the classic road trip experience.

Photo: unsplash.com/@zoshuacolah

#4 – Lincoln Highway

The Lincoln Highway is the first transcontinental highway in the U.S., running from New York City to San Francisco.

Created in 1913
Sparked the development of infrastructure and tourism
Inspired by later highways like the Interstate system

Today, many sections are still driveable, filled with vintage motels and small-town Americana.

Photo: unsplash.com/@plus

#5 – Blue Ridge Parkway

Winding through the Appalachian Mountains, the Blue Ridge Parkway is often called “America’s Favorite Drive.”

Ideal for fall foliage drives
Connects Great Smoky Mountains National Park to Shenandoah National Park

Visit the Blue Ridge Music Center
Explore traditional Appalachian crafts and music.

Photo: unsplash.com/@ashkned

#6 – Extraterrestrial Highway (Nevada SR 375)

Welcome to one of the quirkiest roads in America — the Extraterrestrial Highway, officially Nevada State Route 375. This desolate stretch runs through the Nevada desert and past the infamous Area 51.

The highway got its nickname in 1996 due to frequent UFO sightings.

Roadside stops include the Alien Research Center and the Little A’Le’Inn in the town of Rachel.

Vast desert landscapes
Starry night skies
The mysterious aura of extraterrestrial legends

Whether you're a believer or a curious traveler, it's an unforgettable drive.

Photo: unsplash.com/@who_is_trent

#7 – Historic Columbia River Highway (Oregon)

The Historic Columbia River Highway, which follows the Columbia River Gorge through Oregon, is known as one of the most beautiful scenic routes in the Pacific Northwest.

Built-in the early 1900s
America’s First Scenic Highway
Designed to complement the natural landscape

Waterfalls and Natural Wonders

Multnomah Falls, Oregon’s tallest waterfall
Vista House at Crown Point
Mossy forests and volcanic cliffs

This short but mesmerizing highway is perfect for a weekend getaway.

Photo: unsplash.com/@karolinabobek

#8 – Road to Hana (Hawaii)

The Road to Hana on Maui is not for the faint of heart but a paradise for the senses.

Winding Roads and Lush Jungle
Over 600 curves and 50 bridges
Rainforest-lined roads with stunning ocean views

Must-Visit Stops

Wai’anapanapa State Park and its black sand beach
Twin Falls and Wailua Falls
Secret beaches, caves, and fruit stands

Plan for a full day or two to explore this slow-paced, nature-immersive drive.

Photo: unsplash.com/@jordanfmcqueen

#9 – Turquoise Trail (New Mexico)

Connecting Santa Fe and Albuquerque, the Turquoise Trail is a National Scenic Byway that takes you through New Mexico’s desert soul.

Madrid: a quirky art town filled with galleries
Cerrillos: a semi-abandoned mining town turned film location

Wide-open skies
Mountain views
Peaceful desert roads

The Turquoise Trail is a haven for creatives, explorers, and those chasing Southwestern charm.

Photo: unsplash.com/@alexmette

#10 – Beartooth Highway (Montana-Wyoming)

Often ranked among the most beautiful drives in America, the Beartooth Highway climbs to nearly 11,000 feet through the Rocky Mountains.

Begins near Red Lodge, Montana, and ends near the northeast entrance of Yellowstone National Park

Glacier-carved valleys
Alpine lakes and snowy peaks
Summer snow and wildlife sightings

It’s a seasonal road, usually open from May to October, and a true high-altitude adventure.

Photo: unsplash.com/@craigk